FU"O<3HMINO
@OC[7WJAW P3"OV O5L7 .?+7
#BJBF C* #AP1 #ABO1

@OC[7WJAW P3"OV O5L7 .?+7 _\ FU"O<3HMINO
H=JB;O%JA F1"S5

'\Y1F393' ,,KIHA H=JB;O%JA
@OC[7WJAW P3"OV O5L7 .?+7
.7-CY ;MA@V E<OF["U^<OU5O :CZ @RQ EK;M5
;O%W ,OIR

'\Y1F4DA' H=JB;O%JA .)EG F1"S5 ,O"O.[ O
J3@MAH=JB;O%J:BJY-,,KIHA- ,=.],MA JY.7 O
.N #C JY




'\Y1F52C' UC!W JA,& DUQH[
#BJBD C* ,NATURE ,REVIEWS ,IMMUNOLOGYN
^1D+IY3 ,MANN I[7W *@MCZ .7CR EO,R7E&O
,R7L3JCZ I3,VR.O^7L3-,,SCFA,'S-O E*:A
;N@/V CY @OC[7! .OA.SB .U.TJ3ICZ L,O1!
^1AJ:/,[BCOI4 M"O EU5N ,S,OAJCZ >A
#AJJ.U @RW EO,R7E&O @)$7W \,Y"! .MR@U
O/IE*" @OC[7WJAZ O \,Y"! ;<K< EG! :CZ
^7^SB! .N,OJBCOI4

#A4 @OC[7WJAO"<3 EMS'Q$8
@OC[7WJA-,FUNC;NAL ,M$IC9E-Z .O1^]W
.[7L7O <CQ @Z^( P3Q-,ROOT ,CAUSE-!
H5@MJCZ ,O,[HN5 @O^3 WJAOBCOI4 @O.( WJAO
'EMS'O EG.NQ$8'"<@U EM9CZIE*" @OC[7WJAZ
'VR O EG.N$ ^1,R7JR/CZ$8'"<CZ .O1EGN,S
,O.AJBCOI4
,9/ITUTE = ,FUNC;NAL ,M$IC9E-,,IFM-N,S
@R^1J3 @OC[7WJA ERH["OA,[-,FUNC;NAL
,M$IC9E ,MATRIX-CZ O5L7W$ JV3.<W ^X.BJ3
@)$7 EG.N"! ;N@/.?["U ^G,?J1 ,M O/IU"X
IUBCZ JRA,O5 IU@MOBCOI4 O ERH["OA,[CZ
#G$.O ,R7E&JA.? ,O,[HN5-CUI[-["U @M,]IYS
O/,[BCOI"1 I=JV-,ASSIMIL,N-"
^7S_/^X@M-,DEF5SE @& ,REPAIR-"
NCS.O-,5]GY-" ,R7;N.)JV3-,BIOTRANS=M,N-"
,M,=-,TRANSPORT-" ,UH=-,-MUNIC,N-"
@M.U.? V3.),]-,/RUCTURAL ,9TEGR;Y-4

'\Y1F4CA' *@M @Z@S
,MANN I[7-#BJBD-W ,NATURE ,REVIEWS
,IMMUNOLOGY "O^%N ,I"[E*"
I3,VR.O^7L3-^MHO"NOH[" D["UDOUCNOH["
<,NHNOH[-Z ;,GI3^RA.O1 @\JB
,M+7;N-,,GPCR,'S- ,QJU.)I1@V JO,[H(
H1<,NHO1JVJ+,U-,,HDAC- ?.N"! H=JR .7
.S5EA .7^:A@V .),Q E*:A! .U.TJBCOI4

8'.7-CY ;MA@V E<OF["U^<OU5W >7^7J>7
,UH=! ^U:.MCZ O1"S,[H[ _/OEO.O ;&;S"1
,,AI ,R7,] OEO.O,0


#B4 .7-CY ;MA@V E<OF["U^<OU5W @VJA
.7-CY ;MA-,GUT-,BRA9 ,AXIS-Z .7@V CY LOW
>7^7J>7 ,UH= @]"U"! WEOJBCOI4 O ,UH=Z
,Q@]-EO.M,Q@]-" CR^G^O-JU"[E(-"
E*:A-LOHUF<Q- @]"U"! H=JR O"MS.OE:" .7CR
EO,R7E&Z O EUIZ @]"UN ]J>7! EO;OBCOI4
,DU I[7-#BJBD-W ,9T]N,NAL ,J\RNAL (
,MOLECUL> ,SCI;ES "O^%CZ I3,VR.O^7L3O
:5.[7 .U.TN,S JRA,O5.? :AJ1! J3I@U
^U@UJR/,[BCOI4 H[AJO ^MHO"NOH[CZ .7
L7DO,NDUW .M+ NCS.OP3O1 ,^G <CO"<"
J7:5.[7 .A+7! H=JR .7 .S5EA .7^:A!
$7JVJBCOI4

"I3,VR.O^7L3Z ,OAO" E<OF["U^<OU5" E*:A
$3W L7JU.A+7! *@\JCZ JRA,O5 .U.T.<OBCOI4
OI!W ,M.GO :5.[7,] .O1JV3@V <1"N"[@O
.O1JV3W @\@V"! @\.]J1 ,M O/,[BCOI48
- ,MANN" ,E4 ,R4 I[7" ,NATURE ,REVIEWS
,IMMUNOLOGY -#BJBD-

'\Y1F4A1' JRA,O5 @RC:5"1
I3,VR.O^7L3-,,SCFA,'S-W .A+7 ENFSCO.[5

^MHO"NOH[-,BUTYRATE-"1 .7 L7DO,NDUW .M+
NCS.OP3" J7:5.[7 .A+7" .7^:A @OC[7 $7JV
D["UDOUCNOH[-,PROPIONATE-"1 $3N,S
DUIUI7,Q,R7JB,] .U.T" ,OA+A .U.T JU"[E(N
]J>7
<,NHNOH[-,ACETATE-"1 E1;U .U.OA["U
OI=J<: .O.O1 IRL .U.T" NCS.O J7L7,] %.O

#C4 @OC[7WJA ERH["OA,[W O5L7 .?+7
@OC[7WJAN,SCZ .O1^]W P3Q! ,,ATM
D["NO5PF["U ^G,?JBCOI"1
,)JR7+Q-,ANTEC$5TS" %.).?@*JV3@].? ,UQ-"
;X^1+Q-,TRI7]S" $5:5@*,[H["N,[@*IX,U-"
ER@R_/.O,X+Q-,M$IATORS_/,P]PETUATORS"
:5.[7@*JU"[E( ^&@%3J]-4 O ,N $.O +,U"!
H<O5"<QN ^R;OJE* JV3.<W @)$7 ,SL-,H1L?
,N>RATIVE-$ V3,]IYBCOI4

@M^G@O.( WJA@OC[7WJA

.SB@Z ^7,OA
.O1^] .M7,O5 -,41SE-,C5T]$-
JV3. .M7,O5 -,PATI5T-,C5T]$-

;O"+ EXD+
.[7L7 V3JV
@Z^( P3Q JR@\

.QI3 IU@M
D+.GJVIY3 @S5L
@RQJVIY3 ^<OUEFS

;O"+ ^7^SB
>AE& .M7,O5
,R7JV1,[B@V3 "6 ]>7 "6 DO1+,O >AE&

#D4 E<OF["U^<OU5 ;O"+.NW EO"R
O]R-#BJBD-W ,,BRIC ,VIEW ^U@U,SN ,I"[E*"
E<OF["U^<OU5 ;O"+.N *@M$ .) ,N@/.?["U
JV1^1JO .QJR7IY@U O/,[BCOI4 #BJBB C*
,,FDA$ ,N@/ ;Y;U"U E<OF["U^<OU5 ,Q>A!
,[7QJ3 OJM" D["U^<OUHOA,["
D["O^<OUHOA,[" ,Q^<OUHOA,["
DU,[H[^<OUHOA,[ I[7 I<>7J3 %J]W ;O"+.N$
@R^1IY@U O/,[BCOI4
,COLL9S I[7-#BJBD-Z ,! ,GUT-,BRA9 ,AXIS
#B D3N,S ,R7R ;U@O E<OF["U^<OU5W .M7+,]!
$7.UJR/,[BCOI4 ;&,R7 ^7,OA" ,M% ^7^SB"
J7,R7.N L+7 I[7O .7CR EO,R7E& @M,]N
]J>7! EO;OE:" OCZ D],R7 @)$7N .O,X.?Q
]J>7! .MBCOI4

#E4 ,O1;) $C[7J3 .?+7 ^7^SB
'\Y1F4CC' .7-CY ;MA @)$7! MRJ3
,R7JV1,[B@V3 .)">A

,OAO,S5% ,SB;MR .[7$"1 J"M #CJ;G OL7W
,OAO,S5%-H=@XE&" ;R,U" F="%-"! ,SB;MRJ<:
%OA@%3W E?O"! .N@=JBCOI4
^1J+,OADM5 DUJ5"1 @O5;O" IY3.7" +@SH[
I[7 ^1J+,OADM5! ERO1 ,OAI3N DUJ5J<:
D["U^<OUHOA,["! ^U;M7JBCOI4
,[H["N,[ @V3"O"1 E3,] ,[H["N,[CZ .7
HM@V,]! .[7$,OFOE["U" E]L7OC JUJ[B
GI=["U ^M@+$5,Q@]! JV1,]JVJBCOI4
;M7^GJ3 ,ME*"1 #G-I,O$3W >7.O1W ,ME*Z
.7CR EO,R7E& I<>7,] %.ON DO1,M.?OBCOI4

'\Y1F3AF' @OIR J+@V

.7 .S5EA .7^:A @OC[7 $7JV"U
.7CM,M.[7JM@G /^7
I3,VR.O^7L3 ,R7L3 .[7$"U J7:5.[7 J+@V
.7-CY ;MA ,UH= @R,)["U @O^G EO2 Q.O
@OC[7 J>7L7

'\X26A0''\XFE0F' .MWLJ7 EO2 @U":LJ7

D["U^<OUHOA,[ ^U;M7.NCZ @RQW @)$7 L7HRN
,I"< J+@V$ I"! ,M O/,[BCOI4
E*:A?.N L7HRO@SC .M7JV3.<W @]M
D["U^<OUHOA,[ L+7 .) .)EG$ L7I5O
DO1+JBCOI4
@[B@:AJ3 ,OAO ^*JVCZ O1,O.?Q ,UJV ^&D*!
%^1J1 ,M O/[E["U .S5.Q.?["U
^*JV,OFOBCOI4
.)EG.?Q .QI3OC ;O"+$ DO1+J3 @]M ^3I[,O
W"+ .)EG$V L7I5J,O@O ^"<BCOI4

ERK[5E1
@OC[7WJAZ 'VR <DZ$8'"<CZ @Z^(.? .O1EGN,S
;&^1J<:" $A @RQW @U%J3 ,R7JVJA.? H[A,]N
EKCZ EK;M5J] ;O"+"! .N@=JBCOI4 .7-CY
;MA@V E<OF["U^<OU5 *@MW ^1.)Z [5,OAO @U9
>AO IY1 ,M O/[5! @VJA.?["U .[7E]J@U
O/,[BCOI4
H=JB;O%W @V3.S5N,S @OC[7WJAZ .)H=.?
.OJ/V J*IR @VJAW E3C5.S5OBCOI4 M"O EU5W
.<* ;O%":A! ,Q"YJIY" @VJA.? @Z@SN @O^3J3
.SB@Z^SB["U @)$7! ;Y.?JVJ1 ,M O/,[BCOI4
I<[5 F1"S5N,SCZ 'I=>7WJA@V ,S>7WJAW
H=JB.? .SB@Z'N IRJR <1<^UE:" [5>7UJR7@V
@]"<A O"(! J*IR ,Q@]@VJAW "N3.["U
.R.UE]JR ^U@N/,[BCOI4

'\Y1F4DA' ;<5@UEGJ)

,MANN" ,E4 ,R4" ,LAM" ,Y4 ,K4" @&
,UHLIG" ,H4 ,H4 -#BJBD-4 ,%ORT-*A9 FATTY
ACIDS"1 L9K+ DIET" ! MICROBIOME &
IMMUN;Y4 ,NATURE ,REVIEWS ,IMMUNOLOGY"
#BD-#H-" #EGG-EIE4
,DU" ,Y4" ,HE" ,C4" ,AN" ,Y4" ET ;AL4
-#BJBD-4 ,! ,ROLE ( ,%ORT ,*A9 ,FATTY
,ACIDS 9 ,9FLAMM,N & ,BODY ,H1L?4
,9T]N,NAL ,J\RNAL ( ,MOLECUL> ,SCI;ES"
#BE-#AC-" #GCGI4
,COLL9S" ,J4 ,M4" ,CRYAN" ,J4 ,F4" @&
,O',MAHONY" ,S4 ,M4 -#BJBD-4 ,IMPORT.E
(! MICROBIOTA 9 E>LY LIFE & 9FLU;E ON
FUTURE H1L?4 ,9 ,! ,GUT-,BRA9 ,AXIS
-#BND $4" PP4 #CG-GF-4 ,ACADEMIC ,PRESS4
,9/ITUTE = ,FUNC;NAL ,M$IC9E4 -#BJBD-4
,FUNC;NAL ,M$IC9E ,MATRIX & ,CL9ICAL
,TOOLS4 ,RETRIEV$ F

'\Y1F680' I<[5 F1"S5 /@U
"I=>7WJA@V ,S>7WJAW H=JB.?
.SB@Z"--[5>7UJR7@V @]"<A O"(W J*IR
@VJA.? .RJR,?

'\Y1F4DE' #JGJ-HJFE-BIAG _\ '\Y1F4E7'
_+KIHA-GO@NAVER.COM_: _\
J3@MAH=JB;O%J:BJY-,,KIHA- *@MHO5
H=JB;O% .)EG F1"S5 ,O"O.[ _\ .)H= .OJ/ *
J*IR @VJA %7JB *@M

^C #BJBE J3@MAH=JB;O%J:BJY-,,KIHA- *
FU"O<3HMINO